Handcuffing the Foundations
نویسندگان
چکیده
منابع مشابه
Handcuffing reversal is facilitated by proteases and replication initiator monomers
Specific nucleoprotein complexes are formed strictly to prevent over-initiation of DNA replication. An example of those is the so-called handcuff complex, in which two plasmid molecules are coupled together with plasmid-encoded replication initiation protein (Rep). In this work, we elucidate the mechanism of the handcuff complex disruption. In vitro tests, including dissociation progress analys...
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15 صفحه اولMolecular handcuffing of the relaxosome at the origin of conjugative transfer of the plasmid R1162.
The assembly of plasmid-encoded proteins at a unique site (oriT) on the plasmid R1162, to form a complex called the relaxosome, is required for conjugative transfer of the plasmid and for negative regulation of neighboring promoters. Two-dimensional chloroquine gel electrophoresis was used to show that oriTs are physically coupled at the relaxosome. This interaction requires all the relaxosome ...
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ژورنال
عنوان ژورنال: Science
سال: 1969
ISSN: 0036-8075,1095-9203
DOI: 10.1126/science.165.3888.9